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Professor John Benson
Consultant Breast Surgeon

MA DM (Oxon) MD (Cantab) FRCS (Eng) FRCS (Ed)

 

Appointed as Professor of Applied Surgical Sciences (Anglia Ruskin University) in 2010 – Personal Chair.

I am a full time Consultant Breast Surgeon within the Cambridge Breast Unit, having previously held a joint appointment between Addenbrooke’s and Hinchingbrooke Hospitals from May 2000 until March 2006. I received my Doctorate (DM) from Oxford University and underwent specialist training at the Royal Marsden Hospital and the Institute of Cancer Research, London under the auspices of Professor Michael Baum. Further experience was gained in management of breast diseases as Visiting Professor at the New York Hospital - Cornell Medical Centre in New York. I am Fellow and Director of Clinical Studies at Selwyn College, Cambridge and was appointed a Regional Breast Tutor by the Royal College of Surgeons of England in 2007. I am a Fellow of the Royal College of Surgeons of England and Edinburgh and an examiner for the Intercollegiate Membership Examination (MRCS). I am a member of the British Breast Group and the American Association for Cancer Research.

I have published widely in the field of breast diseases and have recently coordinated a major article on breast cancer for The Lancet. I am a member of the International Advisory Board for The Lancet Oncology and regularly review major grant applications for Breast Cancer Campaign and Cancer Research UK. 

Appointed as Professor of Applied Surgical Sciences (Anglia Ruskin University) in 2010 – Personal Chair.

Member of Faculty for MS in Oncoplastic Breast Surgery Programme.

Publications Late 2009 - Late 2011

Papers/articles

Benson JR. Will ductal carcinoma in situ defeat breast cancer screening? BMJ 2009; 338: 615 

Benson JR.  Managing the contralateral breast in a gene mutation carrier with breast cancer (FEATURE ARTICLE).  Advances in Breast Cancer ; March 2009  1 – 7

Benson JR and Liau S-S.  Cancer Genetics [COMMISSIONED ARTICLE].  Current Topics in Surgery 2010; 88: 681 – 704

Winter ZE, Benson JR, Pusic A.  A systematic review of the clinical evidence to guide treatment recommendations in breast reconstruction based on patient reported outcome measures and health related quality of life.

Ann Surg 2010; 252: 929 - 42  [IMPACT FACTOR 8.4] (collaborative publication with colleagues from the University of Bristol and Memorial Sloan-Kettering Cancer Centre, New York)

Benson JR.  An alternative to axillary lymph node dissection.
Lancet Oncol  2010; 11:908 - 909

Benson JR, Wishart GC. Is intra-operative nodal assessment essential in a modern breast practice? Eur J Surg Oncol  2010; 36: 1162 – 1164

Benson JR, Wishart GC. Is intra-operative nodal assessment essential in a modern breast practice? Response to correspondence. Eur J Surg Oncol  2011; 37: 453

Benson JR, Teo K.   Breast cancer local therapy: What is it’s effect on mortality? 
World J Surg 2011; (in press)

Benson JR. Diagnosis and local management of breast cancer: part II (conference scene). Future Oncol 2011; 7: 959-61

Benson JR. Diagnosis and local management of breast cancer: part I (conference scene). Future Oncol 2011; 7: 955-7

Benson JR, Wishart GC.   Axillary dissection for node positive patients with early stage breast cancer (leader article). Br J Surg  2011; doi:10.1002/bjs.7684

Winters ZE, Haviland J, Reece-Smith A, Betambeau N, Choudhry  K, Chaudhry A , Mills J , Benson JR , Galea M, MacMannus P, Nicholson S, Weiler-Mithoff E, Rayter Z, Thomson  H.  Multi-centre prospective cohort study evaluating the integration of Patient Reported Outcome Measures (PROMS) with key clinical outcomes after types of immediate Latissimus Dorsi (LD) breast reconstruction and the effects of post-mastectomy radiotherapy.  Br Med J (submitted August 2011)

Abstracts

Winters ZE, Mills J, Haviland J, Reece-Smith A, Greenslade M, Benson JR et al.   A Multicentre Prospective Longitudinal Study Establishing Level II Evidence of Health Related Quality of Life after Types of Immediate Latissimus Dorsi (LD) Breast Reconstruction.  Cancer Res 2009; 69: 682S

Benson JR, Wishart GC, Forouhi P, Provenzano E.  How often does a positive lymph node biopsy prompt an isolated delayed axillary lymph node dissection? Eur J Cancer 2010; 8: No. 6  28

Benson JR, Wishart GC, Ambler G, Provenzano E.  Sentinel lymph node biopsy before primary chemotherapy in breast cancer patients. Eur J Cancer 2010; 8: No. 6  29

Winters ZE, Mills J, Haviland J, Reece-Smith A, Greenslade M, Benson JR et al.   A Multicentre Prospective Longitudinal Study Evaluating Health Related Quality of Life after Immediate Latissimus Dorsi (LD) Breast Reconstruction.   Eur J Cancer 2010; 8: No. 6  34

Benson JR, Wishart GC, Forouhi P, Provenzano E.  How often does a positive lymph node biopsy prompt an isolated delayed axillary lymph node dissection? Cancer Res 2010; 70: 135S

Wishart GC, S-W Loh, P Britton, Benson JR.   Fluorescence mapping with indocyanine green (ICG) for sentinel lymph node detection in early breast cancer. Eur J Surg Oncol 2011; 32: S4

Winters ZE, Chaudhry A, Massey E, Benson JR.  A systematic review of patient reported outcome measures (PROMS) and clinical outcome reporting in breast reconstruction. Eur J Surg Oncol 2011; 32: S16

Books

“Management Options in Breast Cancer – case histories, best practice and clinical decision-making” Benson JR, Jatoi I.  Informa Healthcare, New York [ISBN -10:0-415-42310-4]. (2009)

“Oncoplastic and Reconstructive Surgery of the  Breast  (Querci della Rovere G, Benson JR and Nava M Eds)  Informa Healthcare [ISBN 9780415477284] (published December 2010)

Publications 2007 - 2009

Articles

Benson JR and Querci della Rovere G.  Management of the axilla in women with breast cancer.  Commissioned review article incorporating collective viewpoints from local opinion leaders in the UK, USA, Europe and Australasia  Lancet Oncology 2007;  8:  331 – 348

Benson JR and Ravisekar O.  Aromatase inhibitors in the treatment of breast cancer.  Comissioned article for Current Cancer Treatment Reviews 2007;  3:  67 – 79

Benson JR.   Breast cancer and novel therapeutic treatments (GUEST EDITORIAL). European Oncological Disease 2007;  Issue 1 22 – 26

Querci della Rovere G, Biswas N, El-Zayat A, Benson JR.   Technical modifications of the “Grisotti” advancement-rotation flap.   Indian J Surg 2007; 69: 160 - 162

Querci della Rovere G, Nava M, Bonomi R, Catanuto G and Benson JR.  Skin reducing mastectomy with breast reconstruction and sub-pectoral implants.  accepted J Plast Reconstr Aesthetic Surg 2008; 61: 1303 - 1308

Querci della Rovere G and Benson JR.  Management of the axilla in women with breast cancer.  Breast  2007; 16: 130 - 136

Benson JR and Querci della Rovere G.  Ipsilateral breast tumour recurrence. Breast  2008;  17:  12 – 18

Benson JR.   Ovarian ablation as non-surgical treatment for breast cancer. Lancet Oncology 2008;  9: 80

Benson JR and Shamim Absar M.  Volume replacement and displacement techniques in oncoplastic surgery.   Advances in Breast Cancer 2008 (March); 1 - 8

Benson JR and Liau S-S.  Cancer Genetics: A primer for surgeons. Surgical Clinics of North America 2008;  88:  681 – 704

Coles CE, CB Wilson, Cumming J, Benson JR, Forouhi P, Wilkinson JS, Rena R, Wishart GC. Titanium clip placement to allow accurate tumour bed localization following breast conserving surgery – audit on behalf of the IMPORT Trial Management Group.   Eu J Surg Oncol  e-pub 2008

Britton PD, Goud A, Godward S, Barter S, Freeman A, Gaskarth M, Rajan P, Sinnatamby R, Slattery J, Provenzano E, O’Donovan M, Pinder S, Benson JR, Forouhi P, Wishart GC. Use of ultrasound-guided axillary node core biopsy in staging of early breast cancer. Eur Radiol 2008; DO1  10.1007/s00330-008-1177-5

Britton PD, Provenzano E, Barter S, Gaskarth M, Goud A, Moyle P, Sinnatamby R, Wallis M, Benson JR, Forouhi PF, Wishart GC.  Ultrasound-guided percutaneous axillary lymph node core biopsy: how often is the sentinel lymph node being biopsied?   The Breast (epub November 2008)

Benson JR, Jatoi I, Keisch M, Esteva FJ, Makris A, Jordon VC.   Early Breast Cancer.   Lancet 2009; 373: 1463 - 1479

Books

Benson JR, Jatoi I.  ‘Management Options in Breast Cancer - Case histories, Best Practice and Clinical Decision-Making.’   Informa Healthcare, New York [for publication March 2009]

Book chapters

Benson JR.   Chapter entitled “Breast” in “Essential Surgery”  (Burkitt HG and Quick CRG  Eds)  Churchill Livingston Publishers  (4th Edition) 2008

Benson JR.   Chapter entitled “Breast” in “Applied Basic Science for Basic Surgical Training”  (Andrew T. Raftery Ed)  Churchill Livingston Publishers  (2nd Edition) (for publication 2008)

Benson JR and Liau SS.  Chapter entitled “The Nature and Development of Cancer” in “The Oxford Textbook of Medicine”  (T Cox T Editor)  Oxford University Press Publishers  (New Edition) (for publication 2009)

Benson JR, Turner EH, Winters ZE. Chapter entitled “Side effect of Tamoxifen and Anastrozole” in “Methods of Cancer Diagnosis, Therapy and Prognosis”  (Hayat MA Ed)   Springer Company Publishers  (1st Edition) (for publication 2009)

Benson JR, Pitsinis V.  Chapter entitled “Management of the axilla” in “Manual of Breast Diseases” (Jatoi I Ed) Lippincott Williams & Wilkins Publishers (2nd Edition)  (in preparation)

Publications (pre 2007)

Articles

Benson JR. Will ductal carcinoma in situ defeat breast cancer screening? BMJ 2009;  338: 957

Benson JR and Baum M.  Breast cancer, desmoid tumours and Familial Adenomatous Polyposis - a unifying hypothesis.  Lancet   1993;  342:   848 - 850

Benson JR and Baum M.  Transforming growth factor ß isoforms in breast cancer. Br J Cancer   1994;   70:  1278

Colletta AA, Benson JR and Baum M. Alternate mechanisms of action of antioestrogens. Breast Cancer Research and Treatment  1994;  31:  5 - 9  

Benson JR Baum M and Colletta AA.   Stromal - Epithelial Interactions in Carcinogenesis.    Cancer Topics   1996;  10: No.5   10 - 12

Benson JR Transforming growth factor ß: Prospects for Cancer Prevention and Treatment. [Leading Article]  Clinical Immunotherapeutics   1995;  4:  No.4   249 - 258

Benson JR and Wells K.  Microsatellite instability and a TGFß receptor - clues to a growth control pathway.   BioEssays   1995;  17: No. 12  1009 - 1012

Benson JR, Wakefield LM, Baum M and Colletta AA.  Synthesis and secretion of TGFß isoforms by primary cultures of human breast tumour fibroblasts in vitro and their modulation by tamoxifen.  Br J Cancer    1996; 74:  352 - 358

Benson JR, Baum M and Colletta AA.  Role of the TGFß’s in the anti-oestrogen response /resistance of human breast cancer. In: “The TGFß system in breast development, function and tumorigenesis” Journal of Mammary Gland Biology and Neoplasia  1996;  1: No. 4  379 - 387

Benson JR and Colletta AA.  Changes in expression of transforming growth factor beta mRNA isoforms in patients undergoing tamoxifen therapy.  Br J Cancer  1997;  75:  776 - 777

Benson JR   How to express oestrogen receptor activity.    Br J Cancer 1997;  76:  418 - 419

Benson JR    Tamoxifen in early breast cancer.    Lancet   1998;  352:  404 - 405

Benson JR and Osborne MP.   Radiation-induced sarcoma of the breast following conservation surgery.  Breast Cancer Res Treat   1999; 54: 293

Benson JR and Querci della Rovere G.   Classification of Isolated Tumor Cells and Micrometastases (comment).   CANCER   2000;  89:  No. 3   707 - 709

Benson JR and Purushotham A.   Trends in breast cancer incidence, survival and mortality.  Lancet   2000;  356:  590 - 593

Benson JR, Purushotham A and Warren R.  Screening and litigation - The rate of interval cancers is too high.    BMJ   2000;  321:  760 - 761 

Querci della Rovere G. and Benson JR   Tangential or parallel approach for fine needle aspiration cytology of breast lesions.  The Breast   2001;  10: 352 - 355

Benson JR.  Five versus more than five years of tamoxifen for lymph node-negative breast cancer: updated  findings of the National Surgical Adjuvant Breast and Bowel Project B-14 randomised trial (comment).   J Natl Cancer Inst  2001;  93 (19):  1493 - 1494

Benson JR and Querci della Rovere G.  The biological significance of ipsilateral local recurrence of breast cancer: determinant or indicator of poor prognosis. Lancet Oncology   2002;  3: 45 - 49

Benson JR  Recruitment of women into clinical trials. Lancet  2002; 359:  164 - 166

Benson JR.   Tamoxifen for breast cancer in hysterectomised women (letter). Lancet  2002;  360: 1784 - 1785

Benson JR. The effects of tamoxifen and estrogen on brain  metabolism in elderly women.  J Natl Cancer Inst 2002; 94:  67

Benson JR and Pitsinis V. Update on the clinical role of tamoxifen (review article)  Current Opinion in Obstetrics and Gynaecology   2003;  15:  13 - 23

Benson J R  The role of TGFß and breast carcinogenesis.  Lancet Oncol  2004;  5: No.4  229 - 239

Warren RML, Bobrow LG, Earl HM, Britton PB, Gopalan D, Purushotham AD, Wishart GW, Benson JR and Hollingworth W.  Can breast MRI help in the management of women with breast cancer treated by neoadjuvant chemotherapy ?  Br J Cancer  2004;  90: 1349 - 1360

Benson JR.  Skin-sparing mastectomy.  Cancer   2004; ;  101: No. 5  1099 - 1100

Benson JR.   The use of aromatase inhibitors in post-menopausal women with hormone receptor positive breast cancer.   Journal of Clinical Oncology 2005;  23:  6807 – 6809

Querci della Rovere G, Bonomi R, Ashley S and Benson JR.  Axillary staging in women with small invasive breast tumours. Eur J Surg Oncol  2006;  32:  733 – 737

Benson J.R. and Saeb-Parsy K.  Meta-analyses of cancer clinical trials – principles and pitfalls.   Commissioned article (mini-symposium) World Journal of Surgery 2006;  30:  1177 - 1183

Benson JR.   Sentinel node biopsy avoids unnecessary axillary dissection in breast cancer patients. Results of the Milan randomized trial (COMMENTARY). Lancet Oncology 2006; 7:  964 – 966

Books

Benson JR.  ‘TGFß and Cancer’  - book in Medical Intelligence Unitseries. [Landes Bioscience Publishers, Texas, USA]    1998  Chapters 1,2,4,7 and 8     [ISBN: 1-57059-539-9]

“Early Breast Cancer  - from screening to multidisciplinary management “ (Querci Della Rovere G, Warren R and  Benson JR. Eds.)  Taylor and Francis Publishers (2nd Edition) [ISBN 1 84184 384 9]  (published September 2005)  

“Oncoplastic and Reconstructive Surgery  of the  Breast   (Querci della Rovere G,  Benson JR, Breach N and Nava M. Eds)    Preface, editorial and chapters 1, 3, 15 and 17  Martin Dunitz Publishers 2004    [ISBN 1 84184 351 2]  (published March 2004 – best selling title; second edition in preparation)