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Norovirus: visiting restrictions for children under 12

To help protect our patients from the spread of Norovirus and to reduce the risk of bed closures as a result of this infection  we are encouraging parents not to bring their children (under 12 years) to the hospital in March.


Road works on Robinson Way 11-15 March

Robinson Way, the main ring road round the campus, will be reduced to a single lane along two stretches to allow for resurfacing.


Addenbrooke’s nurses showcase work at Florence Nightingale conference

Three Addenbrooke's nurses have had their posters accepted at next week's Florence Nightingale Foundation annual conference.


Head of Audiology is Visiting Professor at University of Toronto

Dr David Baguley, head of audiology has been honoured as a Visiting Professor at the University of Toronto.


Children to have say in clinical research

For the first time children will be given the power to make decisions in the running of a clinical research facility.

 

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Cambridge researchers use genome sequencing to dissect and control an MRSA outbreak

14 November 2012

 

For the first time, researchers from Cambridge have used DNA sequencing to help bring an infectious disease outbreak in a hospital to a close. The approach is much more accurate than current methods used to detect hospital outbreaks and has important implications for the future of infection control.

 

Researchers from Cambridge University Hospitals, the Wellcome Trust Sanger Institute and the University of Cambridge used advanced DNA sequencing technologies to confirm the presence of an ongoing outbreak of methicillin-resistant Staphylococcus aureus (MRSA) in a Special Care Baby Unit in real time. This helped the outbreak to be stopped earlier, preventing possible harm to patients.

 

Using this technology, the team revealed that the outbreak had extended into the wider community, a conclusion that could not be reached with available methods. They also used sequencing to link the outbreak to an unsuspecting carrier, who was treated to eradicate MRSA.

 

Dr Nick Brown, head of infection control at Cambridge University and co-author of the study, said: "We are always seeking ways to improve our patient care and wanted to explore the role that the latest sequencing technologies could play in the control of infections in hospitals. Our aim is to prevent outbreaks, and in the event that they occur to identify these rapidly and accurately and bring them under control.”

 

"What we have glimpsed through this pioneering study is a future in which new sequencing methods will help us to identify, manage and stop hospital outbreaks and deliver even better patient care."

 

Over a six-month period, the hospital infection control team used standard protocols to identify 12 patients who were carrying MRSA. However, this standard approach alone could not give enough information to confirm whether an ongoing outbreak was actually taking place.

 

In this study, the researchers analysed MRSA isolates from these 12 patients with DNA sequencing technology and demonstrated clearly that all the MRSA bacteria were closely related and that this was an outbreak.

 

They also revealed that the outbreak was more extensive than previously realised, finding that more than twice as many people were carrying or were infected with the same outbreak strain. Many of these additional cases were people who had recent links to the hospital but were otherwise healthy and living in the community when they developed a MRSA infection.

 

While this sequencing study was underway, the infection control team identified a new case of MRSA carriage in the Special Care Baby Unit, which occurred 64 days after the last MRSA-positive patient had left the same unit. The team used advanced DNA sequencing to show in real time that this strain was also part of the outbreak, despite the lack of apparent links between this case and previous patients. This raised the possibility that an individual was unknowingly carrying and transmitting the outbreak MRSA strain.

 

The infection control team screened 154 healthcare workers for MRSA and found that one staff member was carrying MRSA. Using DNA sequencing, they confirmed that this MRSA strain was linked to the outbreak. This healthcare worker was quickly treated to eradicate their MRSA carriage and remove the risk of further spread.

 

Dr Julian Parkhill, lead author from the Wellcome Trust Sanger Institute, said: "Our study highlights the power of advanced DNA sequencing used in real time to directly influence infection control procedures.”

 

"There is a real health and cost burden from hospital outbreaks and significant benefits to be gained from their prevention and swift containment. This technology holds great promise for the quick and accurate identification of bacterial transmissions in our hospitals and could lead to a paradigm shift in how we manage infection control and practice."

 

In this instance, DNA sequencing was a key step in bringing the outbreak to a close, saving possible harm to patients and potentially saving the hospital money.

 

Professor Sharon Peacock, lead author from the University of Cambridge and clinical specialist at the Health Protection Agency, said: "Our study indicates the considerable potential of sequencing for the rapid identification of MRSA outbreaks. What we need before this can be introduced into routine care is automated tools that interpret sequence data and provide readily understandable information to healthcare workers. We are currently working on such a system.

 

"If we have a robust system of this type in operation when the outbreaks occur, we predict that we will be able to stop them after the first few cases, as we will rapidly find clear connections."

 

In their next step, the team will study all MRSA carriers and infected patients over the next year in Addenbrooke's Hospital and surrounding hospitals and the community to understand transmission events with the aim of improving infection management.

 

Sir Mark Walport, director of the Wellcome Trust, said: "This is a dramatic demonstration that medical genomics is no longer a technology of the future - it is a technology of the here and now. By collaborating with NHS doctors, geneticists have shown that sequencing can have extremely important applications in healthcare today, halting an outbreak of a potentially deadly disease."

 

 

 

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