Criteria for hereditary diffuse gastric cancer (HDGC) study

Criteria:

• Any family with two documented cases of diffuse gastric cancer in first or second degree relatives with one case under the age of 50.
  
  

• Three or more cases of gastric cancer in the family, diagnosed in any age, with at least one documented case of diffuse gastric cancer.
  
  

• Any individual diagnosed with diffuse gastric cancer before the age of 45 .
  
  

• Any individual diagnosed with both diffuse gastric cancer and lobular breast cancer.
  
  

• One member diagnosed with diffuse gastric cancer and another with lobular breast cancer.
  
  

• One family member diagnosed with diffuse gastric cancer and another with signet ring colon cancer However, if necessary, the research team will seek confirmation of cancer pathologies

 

 

 

Second part of the study

 

This is concerned with families in which a ‘faulty gene’ (mutation) has been identified.

 

The study aims to assess the physical and psychological implications of having a genetic test and the effect on the individual’s quality of life opting for prophylactic surgery or regular endoscopies has.

 

 

 

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