Publications by the team

Histopathological and molecular analysis of gastrectomy specimens from hereditary diffuse gastric cancer patients has implications for endoscopic surveillance of individuals at risk. ME Barber, V Save, F Carneiro, S Dwerryhouse, P Lao-Sirieix, RH Hardwick, C Caldas, and RC Fitzgerald

 

Histopathological and molecular analysis of gastrectomy specimens from hereditary diffuse gastric cancer patients has implications for endoscopic surveillance of individuals at risk. (464 KB)

 

Mechanisms and sequelae of E-cadherin silencing in hereditary diffuse gastric cancer M Barber, A Murrell, Y Ito, A-T Maia, S Hyland, C Oliveira, V Save, F Carneiro, AL Paterson, N Grehan, S Dwerryhouse, P Lao-Sirieix, C Caldas and RC Fitzgerald

 

Mechanisms and sequelae of E-cadherin silencing in hereditary diffuse gastric cancer (461 KB)

 

 

Germline CDH1 deletions in hereditary diffuse gastric cancer families Human Molecular Genetics, 2009, Vol. 18, No. 9.

 

Germline CDH1 deletions in hereditary diffuse gastric cancer families (494 KB)

 

 

Pregnancy after prophylactic total gastrectomy
Springer Science+Business Media B.V. 2010.
Pardeep Kaurah, Rebecca Fitzgerald, Sarah Dwerryhouse, David G. Huntsman

 

Pregnancy after prophylactic total gastrectomy (162 KB)

 

 

Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future research

J Med Genet 2010 47: 436-444.
Rebecca C Fitzgerald, Richard Hardwick, David Huntsman, et al.

 

Hereditary diffuse gastric cancer: updated consensus guidelines for clinical management and directions for future research (162 KB)

 

Identification of Germ-line E-cadherin Mutations in Gastric cancer families of European origin. Cancer Research Sept 15 1998;58:4086-9. Gayther S, Gorringe K, Ramus S, Huntsman D, Roviello F, Grehan N, Machadc J, Pinto E, Seruca R, Halling K, MacLeod P, Powell S, Jackson C, Ponder B, Caldas C.

 

Familial gastric cancer: overview and guidelines for management. Journal for Medical Genetics Dec 1999; 36:873-880. Caldas C, Carneiro F, Lynch H, Yakota J, Wiesner G, Powell S, Lewis F, Huntsman D, Pharoah P, Jankowski J, MacLeod P, Vogelsang H, Keller G,  Park K, Richards F, Maher E, Gayther S, Oliveira C, Grehan N, Wight D, Seruca R, Roviello F, Ponder B, Jackson C.

 

Early gastric cancer in young, asymptomatic carriers of germ-line E- cadherin mutations. N Engl J Med 2001; 344 25:1904-9. Huntsman D, Carneiro F, Lewis F, MacLeod P, Hayashi A, Monaghan K, Maung R, Seruca R, Jackson C, Caldas C

 

Incidence of gastric cancer and breast cancer in CDH1 (E-cadherin) mutation carriers from hereditary diffuse gastric cancer families Gastroenterology 2001; 121 6:1348-53 Pharoah P, Guilford P, Caldas C

 

Screening E-cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindred. Hum Mutat 2002; 19 5:510-517 Oliveira C, Bordin M, Grehan N, Huntsman D, Suriano G, Machado J, Kiviluoto T, Aaltonen L, Jackson C, Seruca R, Caldas C.

 

E-cadherin mutations and hereditary gastric cancer: Prevention by resection? Digestive diseases 2002; 20:23-31 RC Fitzgerald, C Caldas.

 

Clinical implications of E-cadherin associated hereditary diffuse gastric cancer Gut 2004; 53:775-778   R C Fitzgerald and C Caldas.

 

Germline E-cadherin mutations in Hereditary diffuse gastric cancer: assessment of 42 new families and review of genetic screening criteria J Medical Genetics 2004;41:508-517 Brooks-Wilson A, Kaurah P, Suriano G, Leach S, Senz J, Grehan N, Butterfield Y, Jeyes J, Schinas, Bacani J, Kelsey M, Ferreira P, MacGillivray B, MacLeod P,Micek M, Ford J, Foulkes W, Australie K, Greenberg C, LaPointe M, Gilpin C, Nikkel S, Gilchrist D, Hughes R, Jackson C, Monaghan, Oliveira M, Seruca R, Gallinger S,  Caldas C, Huntsman D.

 

A novel mutation in the E-cadherin gene in the first family with hereditary diffuse gastric cancer reported in Spain. European Journal of Surgical Oncology 2006;32: 1110-1113. Rodriguez-Sanjuan JC, Fontalba A, Mayorga M, Bordin MC, Hyland SJ, Trugeda S, Garcia RA, Gomez-Fleitas M, Fernandez F, Caldas C, Fernandez-Luna JL.

 

Familial gastric cancer - clinical management. Best Practice & Research Clinical Gastroenterology 2006; 20: 735-743. Barber M, Fitzgerald RC and Caldas C .

 

Familial gastric cance r- aetiology and pathogenesis. Best Practice & Research Clinical Gastroenterology 2006; 20: 721-734 Barber M, Fitzgerald RC and Caldas C.

 

 

Oral Presentations

 

Barber M, Hyland S, Grehan N, Save V, Caldas C and Fitzgerald RC, Inactivation of the Second Allele in Patients with Hereditary Diffuse Gastric Cancer Harbouring Germline E-cadherin Mutations, Gut, 56 supplement11: A30, 2007

 

Poster Presentations

 

Barber M, Hyland S, Grehan N, Caldas C and Fitzgerald RC, Inactivation of the Second Allele in Patients with Hereditary Diffuse Gastric Cancer Harbouring Germline E-cadherin Mutations, 2nd Prize Winner at the University of Cambridge Graduate School Symposium 2007

 

Barber M, Hyland S, Grehan N, Caldas C and Fitzgerald RC, Inactivation of the Second Allele in Patients with Hereditary Diffuse Gastric Cancer Harbouring Germline E-cadherin Mutations, American Association for Cancer Research Annual Meeting: Proceedings; 2007 Apr 14-18; Los Angeles, CA: AACR; 2007. Abstract 1145

 

Barber M, Hyland S, Grehan N, Save V, Caldas C and Fitzgerald RC, Somatic Mutation as a Possible ‘Second Hit’ in Hereditary Diffuse Gastric Cancer Patients with E-cadherin Germ-Line Mutations, Gastroenterology, 130(4) supplement2: A-638, 2006

 

 

On other sites

 

> Hereditary diffuse gastric cancer: Natural history, pathology, screening limitations, and prophylactic total gastrectomy in CDH1 mutation carriers. American Society of Clinical Oncology (ASCO)

 

 

 

 

 

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