CUH

Radiotherapy Physics

Medical Physics

Box: 152

Cambridge University Hospitals NHS Foundation Trust

Hills Road,

Cambridge,

CB2 0QQ

 

Enquiries: 01223 216 472

 

Fax: 01223 257 137

 

Treatment equipment supported | Planning systems | Imaging systems | Areas of interest | Courses | Recent publications | PhD projects

 

 

Radiotherapy Physics provides a comprehensive Physics service to the Addenbrooke’s Radiotherapy Centre ensuring the safe and accurate use of high dose ionising radiation to treat patients with cancer, whilst maintaining a safe environment for other patients, visitors and staff.

 

Physicists, technicians and radiographers work closely with Oncology staff to provide a wide range of scientific and technical advice and support for all radiotherapy treatments. Routine clinical work includes radiotherapy treatment planning and related dosimetry the provision of brachytherapy, and the manufacture of  immobilisation and shielding equipment for patients.  Extensive support is provided to radiotherapy equipment. This incorporates the design of facilities; the management of computer systems, the design and management of software; and the commissioning, servicing and quality control of Linear Accelerators, Orthovoltage  units, Brachytherapy units and CT scanners.  All our work and related dosimetry are monitored and assured to nationally and internationally agreed specifications and legal requirements.

 

We are involved in research and development in radiotherapy physics, and have PhD students from the University of Cambridge based in our department.

 

We are also responsible for providing radiotherapy physics advice and support to two University Departments (Veterinary Medicine and Pathology).

 

Treatment equipment supported

Addenbrooke’s

Linacs:

  • 1 Varian 600CD (single energy 6MV)
  • 1 Siemens Primus (single energy 6MV)
  • 2 Siemens Primus (6MV and 15MV, plus electrons 6MeV – 21MeV)
  • 2 Siemens Oncor (6MV and 15MV, plus electrons 6MeV – 21MeV)
  • 2 TomoTherapy Hi-Arts

Other equipment:

  • Nucletron HDR brachytherapy
  • Nucletron Seed Selectron
  • Pantak DXT300
  • Lantis (radiotherapy management system)

 

Elsewhere

  • Varian Clinac 1800C at Vet school
  • Pantak DXT300 at Vet school
  • Gulmay 250kV in Peterborough

 

Planning systems

  • CMS Xio
  • TomoTherapy
  • Addenbrooke’s Radiotherapy Planning System (ARPS)
  • ProSoma (outlining and virtual simulation)
  • Various Nucletron Brachy planning systems

 

Imaging systems

  • Toshiba Aquilon wide-bore CT scanner
  • GE Nxi CT scanner
  • Pips Pro
  • Acculoc (gold seed system)

 

Areas of interest

  • Benefits and detriments of Image Guided Radiotherapy.
  • Sources of Uncertainty in Radiotherapy.
  • Integration of 4DCT and PET-CT into treatment planning
  • Development of novel treatment planning techniques
  • Modelling of radiotherapy capacity and demand.

 

Courses

 

Fundamentals of Radiotherapy Planning

 

This course has been run since 2000. The last one was run in November 2010. The next one is provisionally scheduled for 21-23 November 2011, at the Moller Centre in Cambridge. Further details, when available, will be on the RCR web site.

 

> RCR Events

 

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Recent publications

Authors from Addenbrooke’s
Radiotherapy Physics are underlined

 

Published papers

Loo H, Fairfoul J, Chakrabarti A, Dean JC, Benson RJ, Jefferies SJ, Burnet NG.  Tumour Shrinkage and Contour Change during Radiotherapy Increase the Dose to Organs at Risk but not the Target Volumes for Head and Neck Cancer Patients Treated on the TomoTherapy HiArt(TM) System. Clin Oncol (R Coll Radiol). 2010 Oct 5. [Epub ahead of print]

Thomas SJ, Vinall A, Poynter A, Routsis D.  A Multicentre Timing Study of Intensity-modulated Radiotherapy Planning and Delivery.  Clin Oncol (R Coll Radiol). 2010 Oct;22(8):658-65.

Estall V, Fairfoul J, Jena R, Jefferies SJ, Burton KE, Burnet NG.
Skull base meningioma - comparison of intensity-modulated radiotherapy planning techniques using the moduleaf micro-multileaf collimator and helical tomotherapy.
Clin Oncol (R Coll Radiol). 2010 Apr;22(3):179-84.

Donovan EM, Cuirlionis L, Fairfoul J, James H, Mayles H, Manktelow S, Raj S, Tsang Y, Tywman N, Yarnold J, Coles C
Planning With Intensity-Modulated Radiotherapy and Tomotherapy to Modulate Dose Across Breast to Reflect Recurrence Risk (IMPORT High Trial).
Int J Radiat Oncol Biol Phys. 2010 Jun 2. [Epub ahead of print

Eaton D, Twyman N, Thomas S Commissioning a miniature multileaf collimator for small field radiotherapy. Med Dosim. 2010 Spring;35(1):1-6.

Estall VJ, Eaton D, Burton KE, Jefferies SJ, Jena R, Burnet NG Intensity-modulated radiotherapy plan optimisation for skull base lesions: practical class solutions for dose escalation.
Clin Oncol (R Coll Radiol). 2010 May;22(4):313-20

Burnet NG, Adams EJ, Fairfoul J, Tudor GS, Hoole AC, Routsis DS, Dean JC, Kirby RD, Cowen M, Russell SG, Rimmer YL, Thomas SJ.
Practical aspects of implementation of helical tomotherapy for intensity-modulated and image-guided radiotherapy.
Clin Oncol (R Coll Radiol). 2010 May;22(4):294-312

Williams MV, Hoole AC, Dean JC, Russell SG, Thomas SJ, Fairfoul J, Burnet NG.
IMRT can be faster to deliver than conformal radiotherapy.
Radiother Oncol. 2010 May;95(2):257-8.

Jena R, Kirkby NF, Burton KE, Hoole AC, Tan LT, Burnet NG.
A novel algorithm for the morphometric assessment of radiotherapy treatment planning volumes. Br J Radiol. 2010 Jan;83(985):44-51.

Houghton F, Benson RJ, Tudor GS, Fairfoul J, Gemmill J, Dean JC, Routsis DS, Jefferies SJ, Burnet NG.
An assessment of action levels in imaging strategies in head and neck cancer using TomoTherapy. Are our margins adequate in the absence of image guidance?
Clin Oncol (R Coll Radiol). 2009 Nov;21(9):720-7.

Clark CH, Hansen VN, Chantler H, Edwards C, James HV, Webster G, Miles EA, Guerrero Urbano MT, Bhide SA, Bidmead AM, Nutting CM; PARSPORT Trial Management Group.
Dosimetry audit for a multi-centre IMRT head and neck trial.
Radiother Oncol. 2009 Oct;93(1):102-8

Barnett GC, Wilkinson J, Moody AM, Wilson CB, Sharma R, Klager S, Hoole AC, Twyman N, Burnet NG, Coles CE.
A randomised controlled trial of forward-planned radiotherapy (IMRT) for early breast cancer: Baseline characteristics and dosimetry results
Radiother Oncol. 2009 Jul;92(1):34-41

Nguyen TB, HooleACF, Burnet NG and Thomas SJ
The optimization of intensity modulated radiotherapy
in cases where the planning target volume extends into
the build-up region
Phys. Med. Biol. 54 (2009) 2511-2525

Nguyen TB, HooleACF, Burnet NG and Thomas SJ
Dose–volume population histogram: a new tool for evaluating plans whilst considering geometrical uncertainties
Phys. Med. Biol. 54 (2009) 935–947

Tan LT, Coles CE, Hart C, Tait E.
Clinical Impact of Computed Tomography-based Image-guided Brachytherapy for Cervix Cancer using the Tandem-ring Applicator - the Addenbrooke's Experience.
Clin Oncol (R Coll Radiol). 2009 Apr;21(3):175-82.

Thomas SJ, Eaton DJ, Tudor GSJ and Twyman NI. Equivalent squares for small field dosimetry. .  Br J Radiol.81 (2008) 897-901

Rimmer YL, Burnet NG, Routsis DS, Twyman N,  Hoole ACF, Treeby J, Welford D, Fairfoul J, 'Aho T, Vowler SL, Benson RJ.
Practical issues in the implementation of image-guided radiotherapy for the treatment of prostate cancer within a UK department.
Clin Oncol (R Coll Radiol). 2008 Feb;20(1):22-30.

 

Presentations/Posters

D. O’Doherty, L. Tait & J. Fairfoul, Delta4 and Tomotherapy – Our Experience, presentation, IPEM Biennial Radiotherapy meeting, Cardiff July 2010

Barraclough, J.M., Chantler, H. J. & Geater, A. 2010, Dosimetric effects of high density valves in breast radiotherapy treatment planning, IPEM Annual Scientific Meeting, Cardiff, poster presentation

M Cowen*, MV Williams, G Horan, M Mukesh and SJ Thomas “Potential benefits and risks in treating paediatric neuroblastoma patients with IMRT using helical tomotherapy”, ESTRO, Barcelona, September 2010 

S Loo*, G Horan, J Fairfoul, S Tudor, M Lenane, J Dean, M Cowen, S Thomas, N Burnet and M Williams "Craniospinal radiotherapy using helical tomotherapy for paediatric medulloblastoma: developing dose constraints", ESTRO, Barcelona, September 2010 

Eyre K and  Thomas SJ. Comparison of image registration packages for use in radiotherapy planning. IPEM Biennial Radiotherapy meeting,Cardiff University, 6-7 July 2010

M Cowen* and SJ Thomas “Monte Carlo modelling the effect of translational shifts and rotations on prostate dose-population histograms - what margins are required for IGRT?” AAPM, Philadelphia, July 2010 

Chantler H. Advances in the radiotherapy of head & neck cancer: The Addenbrookes experience. Head & Neck cancer: advances in radiation treatment meeting, London, 30 April 2010

Barraclough, J.M., Whitney, D. & Brooke, S. 2009, The Commissioning of 3D Image Guided Brachytherapy for Iridium Wire Treatments, IPEM Brachytherapy in the Modern Era, Manchester, poster presentation

Barraclough, J.M. 2009, The Commissioning of 3D Image Guided Brachytherapy for Iridium Wire Treatments, IPEM Annual Scientific Meeting, Liverpool, oral presentation

Cowen MA*, Williams MV, Horan G and Thomas SJ. “Inclusion of predicted carcinogenic risks in treatment plan optimisation” IPEM MPEC, Liverpool September 2009, (abstract book ISBN 978-1-903613-37-5, p80) 

Thomas SJ, Nguyen TB, Cowen M, Lenane M, Rimmer Y and Burnet NG.  The effect of geometric uncertainties on population TCP for multiple-phase prostate radiotherapy.  ESTRO, Gotteberg, September 2008.

Adams EJ., Fairfoul J, Routsis D, Dean J, Thomas SJ and Burnet NG.  Implementation and initial experience of Tomotherapy.   IPEM Biennial Radiotherapy Meeting.  Bath. September 2008

Set up accuracy measured with 6 degrees of freedom (dof) information for pelvic radiotherapy using tomotherapy on-line image registration D. Routsis, J. Dean, R. Kirby, L. Adams, J. Fairfoul, S. Thomas, S.
Russell, H. Patterson, Y. Rimmer, N. Burnet.  ESTRO, Gotteberg, September 2008

Evaluation of tumour bed localisation and image-guided radiotherapy for breast cancer: the import gold seed study C. Coles, G. Wishart, J. Wilkinson, S. Vowler, J. Vasconcelos, E.Donovan, J. Fairfoul, E. Harris, C. Mackenzie, D. Routsis, A. Poynter, C. Rawlings, N.Twyman, R. Wilks, J. R. Yarnold.  ESTRO, Gotteberg, September 2008

Image-guided radiotherapy (IGRT) for prostate cancer: effect of residual set-up errors and intra-fractional motion on planning target volume (PTV) margins. R. Benson,Y. Rimmer, S. Tudor, J. Dean, N. Muskett, H. Patterson, S. Russell, C. Woodward, J. Fairfoul, A. Doble, N. Burnet ESTRO, Gotteberg, September 2008

The use of a dietary protocol - is there any benefit in prostate radiotherapy with or without image-guidance? Y. Rimmer, R. Benson, A. Lynch, J. Treeby, D. Routsis, J. Fairfoul, A.Hoole, A. Doble, N. Burnet  ESTRO, Gotteberg, September 2008

The import high planning study: defining dose constraints and treatment planning methods for complex breast radiotherapy H. James, L. Ciurlionis, C. Coles, E. Donovan, H. Mayles, Y. Tsang, N. Twyman, J. R. Yarnold.  ESTRO, Gotteberg, September 2008

IMRT plan optimisation for skullbase lesions: planning class solutions. V. J. Estall, N. Burnet, R. Jena, D. Eaton.  ESTRO, Gotteberg, September 2008

Coles CE, Wilkinson JS, Wilson CB, Burnet NG, Twyman N, Hoole ACF, GC Wishart, Moody AM The Cambridge Breast Intensity Modulated Radiotherapy (IMRT) Trial: Dosimetry results. Poster. San Antonio, December 2007 and Presentation Breast cancer campaign conference. Spring 2008.

Carroll HE and Twyman N. Audit of image quality and geometrical accuracy of digitally reconstructed radiographs from different treatment planning systems. IPEM Biennial Radiotherapy Meeting.  Bath. September 2008

Whitney DM   Implementing IGBT for Cervix Brachytherapy, IPEM Brachytherapy The Modern Era, Manchester, 24th Nov 2009

Whitney DM   Dose Optimisation, IPEM Brachytherapy The Modern Era, Manchester, 24th Nov 2009

Whitney DM   Physics Resources for IGBT for Cervix Brachytherapy, IPEM Brachytherapy The Modern Era, Manchester, 24th Nov 2009, Poster presentation.

Barraclough, J.M., Whitney DM   The commissioning of 3D Image Guided Brachytherapy for iridium wire treatments, IPEM Brachytherapy The Modern Era, Manchester, 24th Nov 2009, Poster presentation.

 

Invited Presentations

Whitney DM, The Advantages of Image Guided Brachytherapy of the Cervix, Brit Institute of Radiol., London 13th Oct 2010

Whitney DM, Implementation of Oncentra GYN for 3D Image Guided Brachytherapy of the Cervix, Nucletron Brachytherapy User Meeting, Liverpool, 21st May 2010

Thomas SJ.  Impact of New Technologies on Bunker Design.  IPEM Meeting on “Current developments in the design of radiotherapy treatment room facilities” London 18th March 2009.

Thomas SJ.  Teaching lecture on “Radiotherapy Treatment Planning Algorithms”. IPEM Biennial Radiotherapy Meeting.  Bath. September 2008

 

 

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PhD projects

Completed

 Ian Cowley.

“New approaches to improving the accuracy and outcome of Intensity Modulated Radiotherapy.”

PhD awarded by the Open University 2006.

Supervisors: Simon Thomas, Philip Dendy, Sarah Brooke.

 

Thai-Binh Nguyen. 

“Method of IMRT optimization of shallow tumour cases where the PTV extends into the build-up region”.

PhD awarded by the University of Cambridge 2009.

Supervisors: Neil Burnet, Simon Thomas, Andrew Hoole

 

Current

Mark Cowen - “Image Guided Radiotherapy Using Tomotherapy”.

Due to complete 2011. 

Funded by MRC studentship.

 

Sam Tudor - “Ensuring dosimetric coverage of radiotherapy treatment volumes”. 

Commenced October 2009.

Part time PhD, supported by East of England SHA.

 

(Both with University of Cambridge, Department of Oncology. Supervisor: Simon Thomas)

 

 

 

 

 

 

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Contact us:

 

Enquiries: 01223 216 472

 

Fax: 01223 257 137

 


 

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Information for Part I Clinical Scientist Training in Medical Physics & Clinical Engineering at Addenbrooke’s.