Improving outcomes in transplantation

We will:

1. extend expertise in HLA-A and -B, and leukocyte receptor complex genes to improve outcomes in transplantation through better understanding of MHC gene products on transplant outcome;

 

2. use in vivo and in vitro studies using human tissue to identify novel targets for therapeutic intervention in vascular injury associated with transplantation;

 

3. test novel immunosuppressive agents for their ability to modulate alloimmunity and improve transplant outcome; evaluate techniques developed in the Department of Engineering for evaluation of organ preservation and viability before and after transplantation;

 

4. develop human embryonic stem cells as a source of cells and tissues for clinical transplantation.